Missense point mutations in exons 5-8 of the p53 tumor suppressor gene have been detected in 4 out of 22 (18%) papillary carcinomas developed in the patients with a history of childhood irradiation to the head and neck area (75). Several studies have reported the prevalence of p53 mutations in post-Chernobyl tumors. In one series, PCR-SSCP analysis revealed two (6%) somatic mutations, both in exon 5, in a series of 33 papillary carcinomas (72). One of those mutations was a missense mutation and another was a silent mutation, as detected by nucleotide sequencing. Other studies reported a 0-23% prevalence of mutations in the critical exons of the p53 gene in pediatric post-Chernobyl papillary carcinomas (Table 4) (73, 76, 77). Despite some variation in the results between these observations, the overall prevalence of p53 mutations in this post-Chernobyl population appears approximately 10%. This indicates that inactivation of the p53 tumor suppressor gene has only a limited role in radiation-induced thyroid carcinogenesis.
Was this article helpful?
Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.