Rearrangements of RET and NTRK1 are frequently detected in human papillary thyroid carcinoma. TRK oncogenes involve different activating genes containing
coiled-coil domains chat mediate protein dimerization and consequent tyrosine kinase activation. However, also regions outside the coiled-coil domain contribute to onco-genic activation, with modalities presently under investigation. The high proneness of thyroid epithelium to chromosomal rearrangements might reflect structural and enzymatic properties of thyrocytes with respect to DNA repair. The identification and study of such properties will elucidate the mechanisms responsible for the generation of thyroid oncogenes.
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