Conclusions

The Natural Thyroid Diet

The Natural Thyroid Diet

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Rearrangements of RET and NTRK1 are frequently detected in human papillary thyroid carcinoma. TRK oncogenes involve different activating genes containing

Figure 6. Ideogram of chromosomes 1 and 3 showing the localization of NTRK1, TPM3, TPR and TFG genes. The arrows indicate the transcriptional orientation.

coiled-coil domains chat mediate protein dimerization and consequent tyrosine kinase activation. However, also regions outside the coiled-coil domain contribute to onco-genic activation, with modalities presently under investigation. The high proneness of thyroid epithelium to chromosomal rearrangements might reflect structural and enzymatic properties of thyrocytes with respect to DNA repair. The identification and study of such properties will elucidate the mechanisms responsible for the generation of thyroid oncogenes.

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