Use of Male Sex Hormone Receptor Antagonist

The most widely used male sex hormone receptor antagonist in the treatment of experimental trauma is flutamide. Flutamide blocks receptors of testosterone, dihydrotestosterone, and 3a-androstenediol (Chaudry et al., 2003). Flutamide is a nonsteroidal agent and is known to inhibit androgen uptake or nuclear binding of the activated androgen receptor to nuclear response elements in the nucleus (Kolvenbag and Nash, 1999; Chaudry et al., 2003). It is used clinically for the treatment of androgen-sensitive pro-static carcinoma. Animal studies have shown that treatment of animals with flutamide is effective in preventing the deleterious effects of hemorrhagic shock on cell-mediated immunity, as well as in preventing the cardiovascular and hepatocellular depression (Angele et al., 1997; Angele et al., 1998a, 2000, 2001; Yokoyama et al., 2002; Chaudry et al., 2003). Another common antiandrogenic compound is bicalutamide (AstraZeneca Chicago, IL). Bicalutamide, similar to flutamide, is a nonsteroidal and shares flutamide in its mechanism of action (Furr, 1996; Kolvenbag and Nash, 1999; Angele et al., 2000; Chaudry et al., 2003). It competitively inhibits the binding of androgen to its cytosolic receptor in target tissues and is used clinically in the treatment of prostate cancer.

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