Ubiquitination Pathways

Candidate factors do exist for such a signal. In inter-neuronal synapses, signals including FGFs, WNTs, neurotrophins, and neurexin/neuroligin interactions have been implicated; however, it is unclear to what extent these factors play a role in synaptogenesis at the NMJ. Another system implicated in the determination of presynaptic morphology is ubiquitination62. This was first reported in Drosophila and C. elegans, where mutations in highwire and rpm1 (regulator of presynaptic morphology 1), respectively, cause defects in presynaptic differentiation, leading to ineffective synaptic transmission63-65. The highwire and rpm1 genes encode E3 ring finger ubiquitin ligases. The mammalian ortholog of this gene is protein associated with Myc (PAM)66. An analogous role in mammalian presynaptic differentiation was indicated by an analysis of mice lacking Phr1 (for PAM-highwire-rpm1), generated by combining narrowly overlapping deficiencies67. These mice die at birth with apparently ineffective NMJ synaptic transmission, and defects in both sensory and motor-nerve terminal morphology. How ubiquitination influences presynaptic morphology and synaptic function is intriguing, but largely unanswered.

Drug Addiction

Drug Addiction

If you're wanting to learn about drug addiction... Then this may be the most important letter you'll ever read You Are Going To Get A In Depth Look At One Of The Most Noteworthy Guides On Drug Addiction There Is Available On The Market Today. It Doesn't Matter If You Are Just For The First Time Looking For Answers On Drug Addiction, This Guide Will Get You On The Right Track.

Get My Free Ebook


Post a comment