S

SAP-102, 214, 216, 268 SAP97, 268, 366 SAPAP3 mRNAs, 255 Schaffer collateral synapses, 186 Schizophrenia, 329, 378, 392 cognitive defects in, 393-394 complexins in, 394-399 other molecular markers in,

403-405 pathophysiology of, 393 SNAP-25 responsible for, 400-403 Schwann cell, 23, 25 SER, see Smooth endoplasmic reticulum

Ser818, 369 Serotonin 5-HT, 379 Serotonin 5HTT promoter gene, 420 Sertoli cell proliferation, 447 SH3, see Src-homology-3 Shaker-type K channels, 266 Shank proteins, 252, 254, 262,

269-271 Shank2/ProSAP1 mRNA, 254 Silicon chip technologies, utilization of, 40

Single particle tracking experiments,

224 sJMD, 91

Ski, see Skinny hedgehog Skinny hedgehog, 74 S-laminins, 21

Smooth endoplasmic reticulum, 263 SNAP-25, 74, 392 clinical data of, 402-403 physiological functions of, 400-401 preclinical data of, 401-402 presynaptic localization of, 400 SNARE protein Ykt6, 74 SNARE, 394, 400, 426 SNB::GFP, 47 SNB-1, see Synaptobrevin SNK, 342

South Carolina Autism Project, 410-411

Spatial memory acquisition, 359-360 Spinal cord dorsal horn, homosynaptic long term potentiation, 380-381 sensory transmission by, 378-379 serotonin (5-HT)-induced potentiation, 379 synaptic potentiation in, 380 Spinophilin, 270 SPT, see Single particle tracking experiments Sra-1, 260 Sra1/CYFIP1, 252 Src-homology-3, 69 ST8SiaII (STX) enzyme, 105 ST8SiaIV (PST) enzyme, 105 Stargazin protein, 114 Stargazing, 168-169 Stratum lacunosum-moleculare dendrites, 2 Streptococcus pneumoniae, 168

Styryl dyes, 76, 107, 130, 243 SVs, see Synaptic vesicles SYD-2: GFP, see SYnapse

Defective::GFP fusion NMJs reporter SYG-1/SYG-2 homologs, 52 SYnapse Defective::GFP fusion NMJs reporter, 46, 48 Synapse formation, issues in; see also Synaptic components, in synapse formation gene transcription, 36-37

interspecies synaptogenesis between molluscan neurons, 33-34 in vivo regeneration, 30 in vivo synapse formation, 40 in vitro reconstruction of neuronal networks, 31 molluscan cell culture techniques, 31

protein synthesis, 37 soma-soma synapse model, 34 synaptic hierarchy, 33 synaptic number, regulation of, 39 synaptic plasticity, 37-38 synaptic scaling, regulation of, 39 synaptogenic program, effect of, 36 transmitter-receptor interactions, 33 trophic factors, role of, 34-36 Synapse number, for learning and memory acrobatic task acquisition, 352-353 delay eyeblink conditioning, effect of, 353-354 negative results and interpretations, 354-355

skilled reaching paradigm, effect of, 353

spatial memory acquisition, 354 Synapse-associated protein 70, 90, 97, 102

Synapses, 447-449; see also Synaptic components of Amphids Defective, see SAD-1 remodeling of existing, 358-361 synapse bouton formation, effect of, 356-358

synapse number, effect of, 352-355 Synapse-specific glycosylation, 25 Synapsins, 184

Synaptic activity, in nucleus, 340-342 Synaptic cleft, 15, 20-21, 23, 83, 116 Synaptic components, in synapse formation AMPARs, 325-327 CaMKII, 324-325 NMDARs, 325-327 PDZ domains, 321 PSD-95, 322-324 receptor diffusion, 321 Synaptic connectivity, 4 in Munc18-1 deficient mice, 6 nature of, 5 Synaptic cytoskeletal rearrangement, 59-61

Synaptic plasticity and cognitive function, 466-467 Synaptic plasticity-related gene expression, 342-343 Synaptic proteins assembly of, 69-72 monitoring of, in live cultured neurons, 75-78 Synaptic tagging, 343 Synaptic vesicles, 43 Synaptobrevin, 46 Synaptogenesis; see also Synaptic components, in synapse formation axonal pathfinding in, 5-7

ECM signaling, 15-20 interneurons, synapsing of, 3 in morphologic stabilization of dendrites; see Dendrites, morphologic stabilization of neuronal synaptic partners, 3 synapse formation problem, 2-4; see also Synapse formation, techniques in synaptic cell adhesions, 5-8 synaptic connections, nature of, 5 Synapto-nuclear signaling, 337-338 molecules controlling, 338-340 scaffolding proteins in, 337-338 transmembrane proteins in, 337-338 Synaptophysin, 435 SynCAM 1 molecule, 116 domain organization of, 128-129 expression in vertebrate brain, 129 identification of, 127-128

motifs of, 128-129 in synapse formation, 129-132 in synapse induction, 132-133 SynCAM family, 7, 78, 133, 164, 217, 266

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