References375

Chapter 25: LEARNING-INDUCED CHANGES IN SENSORY

SYNAPTIC TRANSMISSION, Min Zhuo 377

1. SUMMARY 377

2. INTRODUCTION 377

3. SPINAL DORSAL HORN: THE FIRST SENSORY SYNAPSE 378

3.1. Sensory Transmission 378

3.2. Serotonin (5-HT)-Induced Potentiation 379

3.3. Homosynaptic LTP 380

4. AMYGDALA: FEAR AND ITS LONG-TERM STORAGE 381

4.1. Amygdala and Fear 381

4.2. Fear and LTP 381

4.3. Thalamic-Amygdala LTP 382

4.4. LTP in the Cortical-Amygdala Pathway 382

5. ANTERIOR CINGULATE CORTEX (ACC): AN INTEGRATIVE CENTER 384

5.1. Synaptic Transmission in the ACC 384

5.3. Behavioral Fear and the ACC 384

6. CHRONIC PAIN 385

7. CONCLUSIONS 387

8. REFERENCES 387

PART VI: SYNAPTOGENESIS AND BRAIN DISORDERS 389

Chapter 26: RELEVANCE OF PRESYNAPTIC PROTEINS TO NEUROPSYCHIATRIC DISORDERS, Alasdair M. Barr, Clint E. Young, Ken Sawada, and William G. Honer 391

1. SUMMARY 391

2. INTRODUCTION 392

3. SCHIZOPHRENIA 393

3.1. Pathophysiology of Schizophrenia 393

3.2. Cognitive Deficits in Schizophrenia 393

4. COMPLEXINS AND SCHIZOPHRENIA 394

4.1. Presynaptic Localization of Complexins 394

4.2. Expression of Complexins in the Brain 395

4.3. Physiological Functions of Complexins 396

4.4. Preclinical Data on Complexins 397

4.5. Clinical Data on Complexins 399

5. SNAP-25 AND SCHIZOPHRENIA 400

5.1. Presynaptic Localization of SNAP-25 400

5.2. Physiological Functions of SNAP-25 400

5.3. Preclinical Data on SNAP-25 401

5.4. Clinical Data on SNAP-25 402

5.5. Association Between Cognitive Function and Expression of Snap-25 and Complexins in Schizophrenia 403

6. CHANGES IN OTHER MOLECULAR MARKERS

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