P

a-Pcdh/CNR isoform, 140-141 p75 pan-neurotrophin receptor, 180, 182

PACSIN1, 461 Paired-pulse facilitation, 382 Palmitolyation, 285 Palmitoyl acyl-transferases, 74 PAM, see Myc protein PAM-highwire-rpm1, 24 Parkinson disease, 378 Parvalbumin-positive basket cells, 282

PATs, see Palmitoyl acyl-transferases PC12 cells, 396

a- and y-Pcdh proteins, 139 P- or y-Pcdh isoforms, 140 Pcdh-a, -P, and -y genes, 138-140, 145

Pcdh-y deletion homozygotes, 143 PDDNOS, see Pervasive development disorder not otherwise specified PDGF, see Platelet-derived growth factor Periactive zone, 44 Pervasive development disorder not otherwise specified, 409-410 Pervasive developmental disorders, 409

Phosphatidylinositol 4,5-

bisphosphate, 158 PI3 kinase, 182, 369 Piccolo-Bassoon transport vesicles, 235

generation of, 243 PICK1, 153, 366, 373 Picket-barrier model, 225 PIX/PAK/GIT1 signaling module, 251

Platelet-derived growth factor, 100 Porc, see Porcupine Porcupine, 74 Porsolt swim test, 421 Postsynaptic Density-95, 51, 69-71, 75-77, 89, 91, 105, 113, 115, 118-120, 141, 144, 204, 210-211, 217-218, 248, 253, 262, 266-270, 283, 289, 322-324, 337, 370, 414, 465 Postsynaptic Receptor Clustering, 55 Postsynaptic scaffold proteins function at synapses, 264-266, 273

molecular interactions of, 248-249 PP1B,324

PPD, see Pervasive developmental disorders PPF, see Paired-pulse facilitation PPI, see Prepulse inhibition Prepulse inhibition, 394 Presynaptic particle web, 141 Primordial active zones, quantal transport of, 241-243 Proline-rich synapse-associated protein, see Shank protein

Protein complexes, at excitatory synapses, 68 Protein kinases and axon geometry, 315-318 and dendrite geometry, 318-320 glutamatergic synapses, recruitment at, 320-327 inhibitory synapses, recruitment at, 327-329 Protein multimerization, 69-70 Protein palmitoylation, 72-73 Protein phosphorylation, 73

effects of, 323 Protocadherin genes cloning of, 138-140 expression and localization of,

140-142 genetic analysis of, 142-146 issues related to, 146-148 protocadherin-42/Pcdh1, 138 protocadherin-43/Pcdh2, 138 Proximal dendrites, 198 PSD molecules, 247 PSD proteins, regulated degradation of, 255

PSD-95, see Postsynaptic density 95 PSD-95/Dlg/ZO-1 homology, 262 ptp-3a isoform, 52 PTV, see Piccolo-Bassoon transport vesicles PTX3, 168

Purkinje cell, 89, 186, 352, 356 Purkinje cell dendrites, 156 abnormal formation of, 303

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