Molecular Mechanisms of Synaptogenesis

Alexander Dityatev Alaa El-Husseini



Alexander Dityatev

University Medical Center Hamburg-Eppendorf 52 Martinistrasse Hamburg 20246 Germany

Alaa El-Husseini University of British Columbia 2255 Wesbrook Mall Vancouver, British Columbia Canada V6T 2A1

Cover illustrations: Front Cover — Numerous Excitatory and Inhibitory Contacts Received by a Single Hippocampal Neuron in Culture. The structure of neurons and location of synapses were visualized by immunostaining against the dendritic microtubule-associated protein MAP2 (blue) and markers of presynaptic excitatory and inhibitory terminals, vesicular glutamate transporter VGLUT1 (green), and vesicular GABA transporter VGAT (red), respectively. Courtesy of Drs. Alaa El-Husseini and Joshua Levinson, University of British Columbia. Back Cover Bottom Right — Ultrastructure of Excitatory and Inhibitory Synapses. Several structures are highlighted: a dendrite and postsynaptic spines (blue), presynaptic excitatory boutons (green), and an inhibitory bouton (red). Courtesy of Drs. Daniel Nicholson and Yuri Geinisman, Northwestern University. Back Cover Top Left — Model Structure of the Neuroligin/ß-Neurexin Trans-Synaptic Complex Together with their Putative Intracellular Binding Partners PSD-95 and CASK. The presynaptic compartment with CASK (yellow) and ß-neurexin (red) is shown in green. The postsynaptic region containing PSD-95 (magenta) and neuroligin (green) is shown in blue. For more details, see Chapter 7, Figure 2. Courtesy of Drs. Markus Missler and Cartsen Reissner, University of Göttingen.

Library of Congress Control Number: 2006920793

ISBN-10: 0-387-32560-3 e-ISBN 0-387-32562-X

ISBN-13: 978-0387-32560-6

Printed on acid-free paper.

© 2006 Springer Science+Business Media, LLC

All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.

Printed in the United States of America. (SPI/EB) 987654321

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