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Synapses/mm3 X 108

Figure 29.3. Relationship Between the Numerical Density of Synapses and Synaptic Apposition Size in the Neocortex of Individuals with Alzheimer's Disease. These graphs are representative of other regions of association cortex. Both laminae III and V show the same relationship. As the number of synapses declines, the size of the residual synapses increases. This may represent a compensatory mechanism used by the disease stricken cortex to maintain total synaptic contact area. The lines represent a simple regression analysis.

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