No overt neurological phenotype
Enhanced hippocampus-dependent spatial learning and trace fear conditioning
No alteration in non-hippocampal-dependent learning and anxiety tasks
Reduced P2/3 and 72 Lack of tonic conductance in cultured hippocampal cells
a5 H105R* (24)
Normal locomotor function Reduction of DZ-induced myorelaxation Facilitated trace fear conditioning
Reduced a5 in hippocampus Reduced P2/3 and 72
Enhanced DZ-induced motor impairment
Post-translational loss of 8 in cerebellum
Reduced a1,P2, P3, and 72 Compensatory increase of TASK-1 K+ leak channels
P2 KO (16)
Viable, fertile, increased locomotor activity No spontaneous seizures
Loss of more than 50% of all GABAA receptors Reduced a1-a6
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