Dominant-negative neuroligin 1

Impairs excitatory but not inhibitory synapses


Neuroligin 2

Overexpression of mislocalized neuroligin 2

Disrupts both excitatory and inhibitory synapses


Role of ß-neurexin

Interfering with neuroligin (1 and 2) function by addition of soluble ß-neurexin - causes clustering of PSD-95 and reduces excitatory and inhibitory synapses


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