Info

11. CONCLUSIONS 306

12. REFERENCES 308

Chapter 21: PROTEIN KINASES AND SYNAPTOGENESIS,

Jochen C. Meier 311

1. SUMMARY 311

2. INTRODUCTION 311

3. NEURON GEOMETRY AND SYNAPSE FORMATION 315

3.1. Protein Kinases and Axon Geometry 315

3.2. Protein Kinases, Dendrite Geometry, and Synapse Formation 318

4. CONTRIBUTION OF PROTEIN KINASES TO SYNAPSE FORMATION BY RECRUITMENT OF SYNAPTIC COMPONENTS 320

4.1. Protein Kinases and Protein Recruitment at Glutamatergic

Synapses 321

4.2. Protein Kinases and Protein Recruitment at Inhibitory Synapses 327

5. CONCLUSIONS 329

6. REFERENCES 330

Chapter 22: SIGNALING FROM SYNAPSE TO NUCLEUS AND BACK, Imbritt K├Ânig and Michael R. Kreutz 333

1. SUMMARY 333

2. INTRODUCTION 333

3. CALCIUM IS THE PIVOTAL MESSENGER THAT TRIGGERS NEURONAL SIGNALING PATHWAYS TO THE NUCLEUS 334

4. SYNAPTIC ACTIVITY AND THE NUCLEAR TRANSLOCATION

5. TRANSMEMBRANE AND SCAFFOLDING PROTEINS OF THE SYNAPSE WITH A POTENTIAL ROLE IN SYNAPTO-NUCLEAR SIGNALING 337

6. MOLECULES AT THE SYNAPSE IN CONTROL OF SYNAPTO-NUCLEAR SIGNALING 338

7. THE STRUCTURAL BASIS FOR INTEGRATING SYNAPTIC ACTIVITY IN THE NUCLEUS 340

8. SYNAPTIC PLASTICITY-RELATED GENE EXPRESSION AFTER SYNAPTIC ACTIVATION 342

9. CONCLUSION AND FUTURE DIRECTIONS 344

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