In Dendrites252

7. SHANK PROTEINS: A CASE FOR LOCAL TRANSLATION OF POSTSYNAPTIC PROTEINS 254

8. REGULATED DEGRADATION OF PSD PROTEINS BY THE UBIQUITIN/PROTEASOME SYSTEM

9. X-LINKED MENTAL RETARDATION

10. CONCLUSIONS AND FUTURE DIRECTIONS

11. REFERENCES

Chapter 18: REGULATION OF DENDRITIC SPINE MORPHOLOGY

AND SYNAPTIC FUNCTION BY SCAFFOLDING PROTEINS,

Stefano Romorini, Giovanni Piccoli, and Carlo Sala 261

1. SUMMARY 261

2. INTRODUCTION 261

3. DENDRITIC SPINE STRUCTURE 262

4. THE FUNCTION OF SCAFFOLD PROTEINS AT SYNAPSES 264

5. THE PSD-95 FAMILY 266

6. THE SHANK AND HOMER FAMILIES 269

7. ACTIN-BINDING PROTEINS 271

8. LESSONS FROM MUTANT ANIMALS AND GENETIC

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