Contents

PREFACE v

CONTRIBUTORS xxiii

COLOR INSERT facing page 246

OVERVIEW: SYNAPTOGENESIS: WHEN LONG-DISTANCE RELATIONS BECOME INTIMATE, Thomas C. Südhof 1

1. SUMMARY 1

2. THE SCOPE OF THE SYNAPSE FORMATION 2

3. THE NATURE OF THE SYNAPTIC CONNECTION 5

4. AXONAL PATHFINDING VERSUS SYNAPTIC CELL ADHESION 5

5. ROLES OF SYNAPTIC CELL ADHESION MOLECULES 7

6. PUTTING EVERYTHING TOGETHER 8

7. REFERENCES 9

PART I: EXPERIMENTAL MODELS OF SYNAPTOGENESIS 11

Chapter 1: THE FORMATION OF THE VERTEBRATE NEUROMUSCULAR JUNCTION: ROLES FOR THE EXTRACELLULAR MATRIX IN SYNAPTOGENESIS, Robert W. Burgess 13

1. SUMMARY 13

2. INTRODUCTION 13

3. SIGNALING BY THE ECM IN SYNAPTOGENESIS: AGRIN 15

3.1. Genetic Tests of the Agrin Hypothesis 16

3.2. Agrin's Postsynaptic Mechanism 17

3.3. Induction versus Stabilization of Postsynaptic Differentiation by Agrin 19

3.4. Extrapolation to Agrin in the CNS 20

4. SUBSYNAPTIC ARCHITECTURE OF THE NMJ: LAMININS 20

4.1. Laminin Proteins 21

4.2. Laminin Localization 21

4.3. Roles for Laminins in Synaptic Organization 22

5. PRESYNAPTIC DIFFERENTIATION FACTORS 23

5.1. Ubiquitination Pathways 24

6. OTHER MECHANISMS AT THE NMJ 24

6.1. ARIA/Neuregulin 24

6.2. Schwann Cells 25

7. CONCLUSIONS 25

8. REFERENCES 27

Chapter 2: SYNAPSE FORMATION BETWEEN IDENTIFIED

MOLLUSCAN NEURONS: A MODEL SYSTEM APPROACH,

Ryanne Wiersma-Meems and Naweed I. Syed 29

1. SUMMARY 29

2. INTRODUCTION 29

3. SYNAPSE FORMATION: LESSONS LEARNED FROM VARIOUS

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