It seems clear that FMRP can play several roles in neuronal functioning, and one of the major thrusts of current research will be to define the RNA and protein partners of FMRP so that we can understand more clearly how it is involved in mRNA translation, export and localization. The role of FMRP in synapse formation is also intriguing, and current efforts to understand how it interacts with mGluR receptors, and the role FMRP plays in the pruning of spines in the developing nervous system, will be exciting developments in FXS research. Clearly these recent efforts have improved our understanding of the effects of FXS on synaptic functioning and have given hope for the development of pharmacological therapies for FXS.*

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