Changes In Apposition Size

Early work on synaptic decline noted that the size of the synaptic contacts in the AD tissue was substantially larger compared to the nondemented controls53'72. Studies in both human and animal work had reported similar findings and suggested it might be part of a compensatory mechanism. As shown in Figure 29.3, there is a significant inverse correlation, such that as the number of synapses declined in a given region, the size of the residual synapses increases. Initially it was thought that this change in synaptic size may be a response found only in late-stage AD subjects. Studies clearly show that this compensatory response not only occurs in control subjects but also can be observed early in the course of the disease17.

Area 9: Alzheimer

Area 9: Alzheimer

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Defeat Drugs Death

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