The Cytochrome P450s

Recent genomic analyses highlight the natural diversity of this family of enzymes. Approximately 4000 different cytochrome P450 genetic isoforms exist in nature, being represented in all forms of life from simple bacteria through to complex eukaryotes. There are at least 50 different human CYPs isoforms, divided into 10 different subfamilies. These enzymes are generally defined as mix-function mono-oxygenases that act together with the cofactor NADPH-P450. In the course of this symposium you will hear of several of these human isoforms including, CYP1A1, CYP2C6, CYP2C13, CYP2D6, CYP2D7 and CYP2E1. The genes coding for these isoforms exhibit commonly occurring genetic variability in human populations that contribute to individual variability in enzyme activity. A review by A. K. Daly summarises the currently known and functionally relevant ones (Daly, 2003).

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