Genetic analysis of dopaminergic system development in zebrafish S Ryu J Holzschuh J Mahler and W Driever

Developmental Biology, Institute Biology 1, University of Freiburg, Freiburg, Germany

Summary. Zebrafish have become an important model organism to study the genetic control of vertebrate nervous system development. Here, we present an overview on the formation of dopaminergic neuronal groups in zebrafish and compare the positions of DA neurons in fish and mammals using the neuromere model of the vertebrate brain. Based on mutant analysis, we evaluate the role of several signaling pathways in catechol-aminergic neuron specification. We further discuss the prospect of identifying novel genes involved in dopaminergic development through forward genetics mutagenesis screens.

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