Chronic Rotenone infusion is an interesting model to study the consequences of systemic complex I inhibition. The scientific interest in the model is justified given the broad spectrum of natural and synthetic compounds in our environment that affect complex I. Regarding the behavioral deficits, the pattern of neurodegeneration and the protein-pathology induced by Rotenone, the similarities with IPD are limited. We believe that Rotenone-treated rats model atypical Parkinsonism rather than IPD, but further work will be necessary to convincingly demonstrate this.

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