Chronic Rotenone infusion is an interesting model to study the consequences of systemic complex I inhibition. The scientific interest in the model is justified given the broad spectrum of natural and synthetic compounds in our environment that affect complex I. Regarding the behavioral deficits, the pattern of neurodegeneration and the protein-pathology induced by Rotenone, the similarities with IPD are limited. We believe that Rotenone-treated rats model atypical Parkinsonism rather than IPD, but further work will be necessary to convincingly demonstrate this.
Was this article helpful?
The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.