A new look at levodopa based on the Elldopa study

Elldopa Study

Department of Neurology, Columbia University, New York, NY, USA Summary. Levodopa has been the gold standard for Parkinson's disease (PD) therapy since it was successfully introduced in 1967. But in the years since then, after recognizing that levodopa often leads to the motor complications of wearing-off and dyskinesias, there have been debates among clinicians as to when levodopa therapy should be started. Delaying therapy was advocated for the purpose of delaying the development of these...

Hypersomnolence excessive daytime sleepiness EDS in PD

Excessive daytime sleepiness (EDS) is a frequent complaint of PD patients. The description of ''sleep attacks'' and motor vehicle accidents in PD patients taking either pramipexole or ropinirole published in 1999 stimulated interest in this topic (Frucht et al., 1999). In one community based study (Tandberg et al., 1999), EDS was seen in 15.5 of PD patients compared to 4 of patients with diabetes mellitus and 1 of controls. EDS was associated with more severe PD, greater PD-related disability,...