1 Jennett B, Teasdale G. Management of head injuries. Philadelphia: FA Davies, 1981.

2 Miller JD, Jones PA, Dearden NM, Tocher JL. Progress in the management of head injury. Br J Surg 1992;79:60-4.

3 Pickard JD, Bailey S, Sanderson H, Rees M, Garfield JS. Steps towards cost-benefit analysis of regional neurosurgical care. Br Med J 1990;301: 629-35.

4 Minns RA. Problems of intracranial pressure in childhood. Clinics in developmental medicine, 113/114. London: MacKeith Press, 1991.

5 Marmarou A, Maset AL, Ward JD, et al. Contribution of CSF and vascular factors to elevation of intracranial pressure in severely head-injured patients. J Neurosurg 1987;66:883-90.

6 Saul TG, Ducker TB. Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury. J Neurosurg 1982;56:498-503.

7 Langfitt TW. Increased intracranial pressure. Clin Neurosurg 1969;16: 436-71.

8 Miller JD, ed. Normal and increased intracranial pressure. In: Northfield's surgery of the central nervous system, 2nd edn. London: Blackwell, 1987;7-57.

9 Miller JD, Dearden NM. Measurement, analysis and the management of raised intracranial pressure. In: Teasdale GM, Miller JD, eds. Current neurosurgery. Edinburgh: Churchill Livingstone, 1992;119-56.

10 Czosnyka M, Richards HK, Czosnyka Z, Piechnik S, Pickard JD. Vascular components of cerebrospinal fluid compensation. J Neurosurg 1999;90: 752-9.

11 Welch K. The intracranial pressure in infants. J Neurosurg 1980;52:693-9.

12 Lundberg N. Continuous recording and control of ventricular fluid pressure in neurosurgical practice. Acta Psych Neurol Scand 1960;36(suppl 149):1-193.

13 Avezaat CJJ, von Eijndhoven JHM, Wyper DJ. Cerebrospinal fluid pulse pressure and intracranial volume-pressure relationships. J Neurol Neurosurg Psychiatry 1979;42:687-700.

14 Lofgren J, von Essen C, Zwetnow NN. The pressure-volume curve of the cerebrospinal fluid space in dogs. Acta Neurol Scand 1973;49:557-74.

15 Rosner MJ, Becker DP. Origins and evolution of plateau waves. Experimental observations and theoretical model. J Neurosurg 1984;60: 312-24.

16 Czosnyka M, Smielewski P, Piechnik S, et al. Hemodynamic characterisation of intracranial pressure plateau waves in head injured patients. J Neurosurg 1999;91:11-19.

17 Newell DW, Aaslid R, Stooss R, Reulen HJ. The relationship of blood flow velocity fluctuations to intracranial pressure B waves. J Neurosurg 1992;76:415-21.

18 Kirkham FJ, Levin SD, Padaychee TS, et al. Transcranial pulsed Doppler ultrasound findings in brainstem death. J Neurol Neurosurg Psychiatry 1987;50:1504-13.

19 Hassler W, Steinmetz H, Pirschel J. Transcranial Doppler study of intracranial circulatory arrest. J Neurosurg 1989;71:195-201.

20 Obrist WD, Langfitt TW, Jaggi JL, et al. Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J Neurosurg 1984;61:241-55.

21 Bingham RM, Procaccio F, Prior PF, Hinds CJ. Cerebral electrical activity influences the effects of etomidate on cerebral perfusion pressure in traumatic coma. Br J Anaesth 1985;57:843-8.

22 Nordstrom CH, Messeter K, Sundbarg G, et al. Cerebral blood flow, vasoreactivity and oxygen consumption during barbiturate therapy in severe traumatic brain lesions. J Neurosurg 1988;68:424-31.

23 Czosnyka M, Piechnik S, Richards HK, Kirkpatrick P, Smielewski P, Pickard JD. Contribution of mathematical modelling to the bedside tests of cerebrovascular autoregulation. J Neurol Neurosurg Psychiatry 1997;63:721-31.

24 Piechnik SK, Czosnyka M, Harris NG, Minhas PS, Pickard JD. A model of the cerebral and cerebrospinal fluid circulations to examine asymmetry in cerebrovascular reactivity. J Cereb Blood Flow Metab 2001; 21:182-92.

25 Ursino M. A mathematical study of human intracranial hydrodynamics. Part 1: The cerebrospinal fluid pulse pressure. Ann Biomed Eng 1988;16:379-401.

26 Czosnyka M, Harris NG, Pickard JD. Carbon dioxide cerebrovascular reactivity as a function of perfusion pressure - a modelling study. Acta Neurochir (Wien) 1993;121:159-65.

27 Guillaume J, Janny P. Manometrie intracranienne continué interest de la methode et premiers resultants. Revue Neurol 1951;84:131-42.

28 Katzman R, Hussey F. A simple constant-infusion manometric test for measurement of CSF absorption. I Rationale and method. Neurology 1970;20:534-44.

29 Borgesen SE, Gjerris F. The predictive value of conductance to outflow of CSF in normal pressure hydrocephalus. Brain 1982;105:65-86.

30 Avezaat CJJ, Eijndhoven JHM. Cerebrospinal fluid pulse pressure and craniospinal dynamics. A theoretical, clinical and experimental study (thesis). The Hague: Jongbloed A, 1984.

31 Ekstedt J. CSF hydrodynamic studies in man. Method of constant pressure CSF infusion. J Neurol Neurosurg Psychiatry 1977;40:105-19.

32 Marmarou A, Shulman K, Rosende RM. A non-linear analysis of CSF system and intracranial pressure dynamics. J Neurosurg 1978;48:332-44.

33 Czosnyka M, Whitehouse H, Smielewski P, Simac S, Pickard JD. Testing of cerebrospinal compensatory reserve in shunted and non-shunted patients: a guide to interpretation based on observational study. J Neurol Neurosurg Psychiatry 1996;60:549-58.

34 Boon AJ, Tans JT, Delwel EJ, et al. Dutch normal-pressure hydrocephalus study: prediction of outcome after shunting by resistance to outflow of cerebrospinal fluid. J Neurosurg 1997;87:687-93.

35 Frieden H, Ekstedt J. Instrumentation for cerebrospinal fluid hydrodynamic studies in man. Med Biol Eng Comput 1982;20:167-80.

36 Raabe A, Czosnyka M, Piper I, Seifert V. Monitoring of intracranial compliance: correction for a change in body position. Acta Neurochir (Wien) 1999;141:31-6.

37 Pickard JD, Teasdale G, Matheson M, et al. Intraventricular pressure waves -the best predictive test for shunting in normal pressure hydrocephalus. In: Shulman K, Marmarou A, Miller JD, et al. eds. Intracranial pressure, IV. Berlin: Springer-Verlag, 1980;498-500.

38 Symon L, Dorsch NWC, Stephens RJ. Pressure waves in so-called low-pressure hydrocephalus. Lancet 1972;ii:1291-2.

39 Robertson C, Narayan R, Contant C, et al. Clinical experience with continuous monitoring of intracranial compliance. J Neurosurg 1989;71: 673-80.

40 Piper I, Miller JD, Dearden M, et al. System analysis of cerebrovascular pressure transmission: an observational study in head injured patients. J Neurosurg 1990;73:871-80.

41 Miller JD, Garibi J, Pickard JD. Induced changes in cerebrospinal fluid volume. Effects during continuous monitoring of ventricular fluid pressure. Arch Neurol 1973;28:265-9.

42 Smielewski P, Czosnyka M, Kirkpatrick P, Pickard JD. Evaluation of transient hyperaemic response test in head injured patients. J Neurosurg 1997;86:773-8.

43 Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD. Monitoring of cerebral autoregulation in head-injured patients. Stroke 1996;27:829-34.

44 Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD. Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery 1997;41:11-19.

45 Czosnyka M, Guazzo E, Whitehouse H, et al. Significance of intracranial pressure waveform analysis after head injury. Acta Neurochir (Wien) 1996;138:531-42.

46 Aaslid R, Markwalder T-M, Nornes H. Non-invasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982;57:769-74.

47 Newell DW, Aaslid R. Transcranial Doppler. New York: Raven Press, 1992.

48 Martin JL, Perry S, Pickard JD. Cerebral blood flow and Doppler flow velocity: different responses to three vasodilators. J Cereb Blood Flow Metab 1991;11(suppl 2):S455.

49 Chan KH, Miller JD, Dearden NM, Andrews PJD, Midgley S. The effect of cerebral perfusion pressure upon changes in middle cerebral artery flow velocity and jugular venous bulb oxygen saturation after severe head injury. J Neurosurg 1992;77:55-61.

50 Dewey RC, Pieper HP, Hunt WE. Experimental cerebral hemodynamics. Vasomotor tone, critical closing pressure, and vascular bed resistance. Neurosurgery 1974;41:597-606.

51 Czosnyka M, Smielewski P, Piechnik S, et al. Critical closing pressure in cerebrovascular circulation. J Neurol Neurosurg Psychiatry 1999;66:606-11.

52 Aaslid R, Lundar T, Lindegaard K-F, et al. Estimation of cerebral perfusion pressure from arterial blood pressure and transcranial Doppler recordings. In: Miller JD, Teasdale GM, Rowan JO, Galbraith SL, Mendelow AD, eds. Intracranial pressure, VI. Berlin: Springer Verlag, 1986;229-31.

53 Czosnyka M, Matta BF, Smielewski P, Kirkpatrick P, Pickard JD. Cerebral perfusion pressure in head-injured patients: a non-invasive assessment using transcranial Doppler ultrasonography. J Neurosurg 1998;88:802-8.

54 Schmidt EA, Czosnyka M, Gooskens I, et al. Preliminary experience of the estimation of cerebral perfusion pressure using trascranial Doppler ultrasonography. J Neurol Neurosurg Psychiatry 2001;70:198-204.

55 Schmidt B, Czosnyka M, Schwarze JJ, et al. Cerebral vasodilatation causing acute intracranial hypertension: a method for non-invasive assessment. J Cereb Blood Flow Metab 1999;19:990-6.

56 Schoser BG, Riemenschneider N, Hansen HC. The impact of raised intracranial pressure on cerebral venous hemodynamics: a prospective venous transcranial Doppler ultrasonography study. J Neurosurg 1999;91: 744-9.

57 Petkus V, Ragauskas A, Jurkonis R. Investigation of intracranial media ultrasonic monitoring model. Ultrasonics 2002;40:829-33.

58 Torikoshi S, Wilson MH, Ballard RE, et al. Ultrasound measurement of transcranial distance during head-down tilt. J Gravit Physiol 1995;2:145-6.

59 Reid A, Marchbanks RJ, Martin R, Pickard JD, Bateman N, Brightwell R. Mean intracranial pressure monitoring by an audiological technique - a pilot study. J Neurol Neurosurg Psychiatry 1989;52:610-12.

60 Wyatt JS, Cope M, Delpy DT, Wray S, Reynolds EOR. Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectroscopy. Lancet 1986;ii:1063-6.

61 Filippi R, Reisch R, Mauer D, Perneczky A. Brain tissue po2 related to Sjvo2, ICP, and CPP in severe brain injury. Neurosurg Rev 2000;23:94-7.

62 Goodman JC, Valadka AB, Gopinath SP, Uzura M, Grossman RG, Robertson CS. Simultaneous measurement of cortical potassium, calcium, and magnesium levels measured in head injured patients using microdialysis with ion chromatography. Acta Neurochir Suppl (Wien) 1999;75:35-7.

63 Reinert M, Khaldi A, Zauner A, Doppenberg E, Choi S, Bullock R. High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. J Neurosurg 2000;93:800-7.

64 Guidelines of the Brain Trauma Foundation. Part 1: Guidelines for the management of penetrating brain injury. Introduction and methodology. J Trauma 2001;51:S3-6.

65 Campkin TV, Turner JM. Neurosurgical anaesthesia and intensive care, 2nd edn. London: Butterworth, 1986.

66 Eisenberg HM, Frankowski RF, Contant CF, Marshall LF, Walker MD. High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg 1988;69:15-23.

67 Marmarou A, Anderson R, Ward J, et al. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J Neurosurg 1991;75:S159-66.

68 Bullock RM, Chesnut RM, Clifton GL, Ghajar J, Marion DW. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2000; 17:451-554.

69 Ropper AH, O'Rourke D, Kennedy SK. Head position, intracranial pressure and compliance. Neurology 1982;32:1288-91.

70 Rosner MJ, Coley IB. Cerebral perfusion pressure, intracranial pressure and head elevation. J Neurosurg 1986;65:636-41.

71 Feldman Z, Kanter MJ, Robertson CS, et al. Effect of head elevation on intracranial pressure, cerebral perfusion pressure and cerebral blood flow in head injured patients. J Neurosurg 1992;76:207-11.

72 Kanter MJ, Robertson CS, Sheinberg MA, et al. Changes in cerebral hemodynamics with head elevated vs head flat. In: Avezaat C, ed. Intracranial pressure, VIII. Berlin: Springer-Verlag, 1993;429-32.

73 Asgeirsson B, Grande PO, Nordstrom CH. A new therapy of post-trauma brain oedema based on haemodynamic principles for brain volume regulation. Intensive Care Med 1994;20:260-7.

74 Juul N, Morris GF, Marshall SB, Marshall LF. Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury. The Executive Committee of the International Selfotel Trial. J Neurosurg 2000;92:1-6.

75 Robertson CS. Management of cerebral perfusion pressure after traumatic brain injury. Anesthesiology 2001;95:1513-17.

76 Rosner MJ, Rosner SD, Johnson AH. Cerebral perfusion pressure: management protocol and clinical results. J Neurosurg 1995;83:949-62.

77 Eker C, Asgeirsson B, Grande PO, Schalen W, Nordstrom CH. Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation. Crit Care Med 1998;26:1881-6.

78 Clifton GL, Miller ER, Choi SC, Levin HS. Fluid thresholds and outcome from severe brain injury. Crit Care Med 2002;30:739-45.

79 Nelson RJ, Roberts J, Rubin C, Walker V, Ackery DM, Pickard JD. Association of hypovolaemia after subarachnoid haemorrhage with computer tomographic scan evidence of raised intracranial pressure. Neurosurgery 1991;29:178-82.

80 Hasan D, Vermeulen M, Wijdicks EFM, et al. Effect of fluid intake and hypertensive treatment on cerebral ischaemia after subarachnoid haemorrhage. Stroke 1989;20:1511-15.

81 Harrigan MR. Cerebral salt wasting syndrome: a review. Neurosurgery 1996;38:152-60.

82 Muizelaar JP. Induced arterial hypertension in the treatment of high intracranial pressure. In: Hoff JT, Betz AL, eds. Intracranial pressure VII. Berlin: Springer Verlag, 1989;508-10.

83 Rosner MJ, Rosner SD. Cerebral perfusion pressure management of head injury. In: Avezaat C, ed. Intracranial pressure, VIII. Berlin: Springer Verlag, 1993;540-3.

84 Shimoda M, Oda S, Tsugane R, Sato O. Intracranial complications of hypervolemic therapy in patients with delayed ischemic deficit attributed to vasospasm. J Neurosurg 1993;78:423-9.

85 Contant CF, Valadka AB, Gopinath SP, Hannay HJ, Robertson CS. Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury. J Neurosurg 2001;95:560-8.

86 Kassell NF, Peerless SJ, Durward QJ, Beck DW, Drake CG, Adams HP. Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension. Neurosurgery 1982;11:337-43.

87 Adams HP Jr, Brott TG, Crowell RM, et al. Guidelines for the management of patients with acute ischemic stroke. A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Circulation 1994;90:1588-601.

88 Fitch W, Pickard JD, Tamura A, Graham DI. Effects of hypotension induced with sodium nitroprusside on the cerebral circulation before, and one week after, the subarachnoid injection of blood. J Neurol Neurosurg Psychiatry 1988;51:88-93.

89 Chesnut RM, Marshall LF, Klauber MR, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 34:216-22.

90 Myers RE. Anoxic brain pathology and blood glucose. Neurology 1976; 34:345.

91 Marie C, Bralet J. Blood glucose level and morphological brain damage following cerebral ischaemia. Cerebrovasc Brain Metab Rev 1991;3:29-38.

92 Murphy PG, Myers DS, Davies MJ, et al. The antioxidant potential of propofol (2,6-diisopropylphenol). Br J Anaesth 1992;68:613-18.

93 Wolf A, Weir P, Segar P, Stone J, Shield J. Impaired fatty acid oxidation in propofol infusion syndrome. Lancet 2001;357:606-7.

94 Cremer OL, Moons KG, Bouman EA, Kruijswijk JE, de Smet AM, Kalkman CJ. Long-term propofol infusion and cardiac failure in adult head-injured patients. Lancet 2001;357:117-18.

95 Varelas PN, Mirski MA. Seizures in the adult intensive care unit. J Neurosurg Anesthesiol 2001;13:163-75.

96 Munch EC, Bauhuf C, Horn P, Roth HR, Schmiedek P, Vajkoczy P. Therapy of malignant intracranial hypertension by controlled lumbar cerebrospinal fluid drainage. Crit Care Med 2001;29:976-81.

97 Sullivan LP, Stears JC, Ringer SP. Resolution of syringomyelia and chiari malformation by ventriculo-atrial shunting in a patient with pseudotumour cerebri and a lumbo-peritoneal shunt. Neurosurgery 1988;22:744-7.

98 Editorial. Cranial decompression. Lancet 1988;i:1204.

99 Guerra WK, Gaab MR, Dietz H, et al. Surgical decompression for traumatic brain swelling: indications and results. J Neurosurg 1999;90:187-96.

100 Gower DJ, Lee KS, McWhorter JM. Role of subtemporal decompression in severe closed head injury. Neurosurgery 1988;23:417-22.

101 Munch E, Horn P, Schurer L, Piepgras A, Paul T, Schmiedek P. Management of severe traumatic brain injury by decompressive craniectomy. Neurosurgery 2000;47:315-22; discussion 322-13.

102 Rittierodt M, Gaab MR. Traumatic brain swelling and operative decompression: a prospective investigation. In: Avezaat C, ed. Intracranial pressure, VIII. Berlin: Springer Verlag, 1993.

103 Schwab S, Steiner T, Aschoff A, et al. Early hemicraniectomy in patients with complete middle cerebral artery infarction. Stroke 1998;29: 1888-93.

104 Higgins JN, Owler BK, Cousins C, Pickard JD. Venous sinus stenting for refractory benign intracranial hypertension. Lancet 2002;359:228-30.

105 Kirkham FJ, Neville BGR. Successful management of severe intracranial hypertension by surgical decompression. Dev Med Child Neurol 1986;28:506-9.

106 Ravassin P, Abou-Madi M, Archer D, et al.Changes in CSF pressure after mannitol in patients with and without elevated CSF pressure. J Neurosurg 1988;69:869-76.

107 Smith HP, Kelly DL, McWhorter JM, et al. Comparison of mannitol regimes in patients with severe head injury undergoing intracranial pressure monitoring. J Neurosurg 1986;65:820-4.

108 Roberts PA, Pollay M, Engles C, Pendleton B, Reynolds E, Stevens FA. Effect on intracranial pressure of furosemide combined with varying doses and administration rates of mannitol. J Neurosurg 1987;66: 440-6.

109 James HE, Harbaugh RD, Marshall LF, Shapiro HM. The response to multiple therapeutics in experimental vasogenic edema. In: Shulman K, Marmarou A, Miller JD, et al, eds. Intracranial pressure, IV. Berlin: Springer Verlag, 1980;272-6.

110 Rosenberg GA. Brain fluids and metabolism. Oxford: Oxford University Press, 1990.

111 Inao S, Kuchiwaki H, Wachi A, et al. Effect of mannitol on intracranial pressure - volume status and cerebral haemodynamics in brain oedema. Acta Neurochir (Wien) 1990;51(suppl):401-3.

112 Bell BA, Smith MA, Kean DM, et al. Brain water measured by magnetic resonance imaging: correlation with direct estimation and change following mannitol and dexamethasone. Lancet 1987;i:66-9.

113 Kaufmann AM, Cardoso ER. Delayed cerebral accumulation of mannitol in vasogenic edema. In: Avezaat C, ed. Intracranial pressure, VIII. Berlin: Springer Verlag, 1993;592-5.

114 Burke AM, Quest DO, Chien S, et al. The effects of mannitol on blood viscosity. J Neurosurg 1981;55:550-3.

115 Miller JD, Leech P. Effects of mannitol and steroid therapy in intracranial volume pressure relationships. J Neurosurg 1975;42:274-81.

116 Muizelaar JP, Wei EP, Kontos HA, Becker DP. Mannitol causes compensatory cerebral vasoconstriction and vasodilatation in response to blood viscosity changes. J Neurosurg 1983;59:822-8.

117 Auer LM, Haselsberger K. Effect of intravenous mannitol on cat pial arteries and veins during normal and elevated intracranial pressure. Neurosurgery 1987;21:142-6.

118 Harrison MJG. Influence of haemocrit in the cerebral circulation. Cerebrovasc Brain Metab Rev 1989;1:55-67.

119 Brown MM, Wade JPH, Marshall J. Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man. Brain 1985;108:81-93.

120 Purves MJ. The physiology of the cerebral circulation. Cambridge: Cambridge University Press, 1972.

121 Bruce DA, Langfitt TW, Miller JD, et al. Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J Neurosurg 1973;38:131-44.

122 Johnston IH, Harper AM. The effect of mannitol on cerebral blood flow. An experimental study. J Neurosurg 1973;38:461-71.

123 Mendelow AD, Teasdale GM, Russell T, et al. Effect of mannitol on cerebral blood flow and cerebral perfusion pressure in human head injury. J Neurosurg 1985;63:43-8.

124 Jafar JJ, Johns LM, Mullan SF. The effect of mannitol on cerebral blood flow. J Neurosurg 1986;64:754-9.

125 Muizelaar JP, Lutz HA, Becker DP. Effect of mannitol on intracranial pressure and cerebral blood flow and correlation with pressure autoregulation in severely head-injured patients. J Neurosurg 1984;61:700-6.

126 Meyer FB, Anderson RE, Sundt TM, Yaksh TL. Treatment of experimental focal cerebral ischaemia with mannitol. Assessment by intracellular pH, cortical blood flow and EEG. J Neurosurg 1987;66:109-15.

127 Takagi H, Saito T, Kitahara T, Morii SM, Ohwada J, Yada K. The mechanism of the intracranial pressure reducing effect of mannitol. In: Ishii S, Nagai H, Brock M, eds. Intracranial pressure, V. Berlin: Springer Verlag, 1983;729-33.

128 Qureshi AI, Suarez JI. Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension. Crit Care Med 2000;28: 3301-13.

129 Shiozaki T, Sugimoto H, Taneda M, et al. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 1993;79:363-8.

130 Marion DW, Penrod LE, Kelsey SF, et al. Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med 1997;336:540-6.

131 Jiang J, Yu M, Zhu C. Effect of long-term mild hypothermia therapy in patients with severe traumatic brain injury: 1-year follow-up review of 87 cases. J Neurosurg 2000;93:546-9.

132 Clifton GL, Miller ER, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001;344:556-63.

133 Matsushita Y, Bramlett HM, Alonso O, Dietrich WD. Posttraumatic hypothermia is neuroprotective in a model of traumatic brain injury complicated by a secondary hypoxic insult. Crit Care Med 2001;29: 2060-6.

134 Shiozaki T, Hayakata T, Taneda M, et al. A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan. J Neurosurg 2001;94:50-4.

135 Muizelaar JP, Marmarou A, Ward JD, et al. Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg 1991;75:731-9.

136 Diringer MN, Videen TO, Yundt K, et al. Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury. J Neurosurg 2002;96:103-8.

137 Coles JP, Minhas PS, Fryer TD, et al. Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates. Crit Care Med 2002;30:1950-9.

138 Cruz J. The first decade of continuous monitoring of jugular bulb oxyhemoglobinsaturation: management strategies and clinical outcome. Crit Care Med 1998;26:344-51.

139 Obrist WD, Langfitt TW, Jaggi JL, Cruz J, Gennarelli TA. Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension. J Neurosurg 1984:61:241-53.

140 Muizelaar JP, van der Poel HG, Li Z, Kontos HA, Levasseur JE. Pial arteriolar vessel diameter and CO2 reactivity during prolonged hyperventilation in the rabbit. J Neurosurg 1988;69:923-7.

141 Enevoldsen EM, Jensen FT. Autoregulation and CO2 responses of cerebral blood flow in patients with acute severe head injury. J Neurosurg 1978;48:689-703.

142 Paolin A, Rodriguez G, Betetto M, Simini G. Cerebral hemodynamic response to CO2 after severe head injury: clinical and prognostic implications. J Trauma 1998;44:495-500.

143 Enevoldsen EM, Cold G, Jensen FT, et al. Dynamic changes in regional cerebral blood flow, intraventricular pressure, CSF pH and lactate levels during the acute phase of head injury. J Neurosurg 1976;44:191-214.

144 De Salles AAF, Kontos HA, Becker DP, et al. Prognostic significance of ventricular CSF lactic acidosis in severe head injury. J Neurosurg 1986; 65:615-24.

145 Akiota T, Ota K, Matsumato A, et al. The effect of THAM on acute intracranial hypertension. An experimental and clinical study. In: Beks JWF, Bosch DA, Brock M, eds. Intracranial pressure, III. Berlin: Springer Verlag, 1976;219-33.

146 Gordan E, Rossanda M. Further studies in cerebrospinal fluid acid-base status in patients with brain lesions. Acta Anaesth Scand 1970;14:97-109.

147 Gaab MR, Seegers K, Goetz C. THAM (tromethamine, "tris-buffer"): effective therapy of traumatic brain swelling. In: Hoff JT, Betz AL, eds. Intracranial pressure, VII. Berlin: Springer Verlag, 1989;616-19.

148 Wolf AL, Levi L, Marmarou A, et al. Effect of THAM upon outcome in severe head injury: a randomized prospective clinical trial. J Neurosurg 1993;78:54-9.

149 Schwartz M, Tator CH, Rowed DW, et al. The University of Toronto Head Injury Treatment Study: a prospective randomized comparison of pento-barbitat and mannitol. Can J Neurol Sci 1984;11:434-40.

150 Ward JD, Becker DP, Miller JD, et al. Failure of prophylactic barbiturate coma in the treatment of severe head injury. J Neurosurg 1985;62:383-8.

151 Eisenberg HM, Frankowski RF, Condant CG, et al. High dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg 1988;69:15-23.

152 Cooper PR, Moody S, Clark WK, et al. Dexamethasone and severe head injury: a prospective double blind trial. J Neurosurg 1979;51:307-16.

153 Saul TF, Ducker TB, Salomon M, et al. Steroids in severe head injury. A prospective randomized clinical trial. J Neurosurg 1981;54:596-600.

154 Braakman R, Schouten HJD, Dishoeck BMV, Minderhoud JM. Megadose steroids in severe head injury: results of a prospective double blind clinical trial. J Neurosurg 1983;58:326-30.

155 Giannotta SL, Weiss MH, Apuzzo MLJ, Martin E. High dose glucocorticoids in the management of severe head injury. Neurosurgery 1984;15:497-501.

156 Dearden NM, Gibson JB, McDowall DG, et al. Effect of high dose dexamethasone on outcome from severe head injury. J Neurosurg 1986;64:81-8.

157 Alderson P, Roberts I. Corticosteroids in acute traumatic brain injury: systematic review of randomised controlled trials. Br Med J 1997;314: 1855-9.

158 Floyd RA, Carney JM. Protection against oxidative damage to CNS by a-phenyl-tert-butyl nitrone and other spin-trapping agents: a novel series of non-lipid free radical scavengers. In: Marangos PJ, Lal H, eds. Emerging strategies in neuroprotection. Boston: Birkauser, 1992;252-72.

159 Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. Oxford: Clarendon Press, 1985.

160 Hall ED. Lazaroids: novel cerebroprotective antioxidants. In: Marangos PJ, Lal H, eds. Emerging strategies in neuroprotection. Boston: Birkauser, 1992;224-37.

161 Roberts I. Aminosteroids for acute traumatic brain injury. Cochrane Database Syst Rev 2000;CD001527.

162 Bath PM, Iddenden R, Bath FJ, Orgogozo JM. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev 2001;CD002087.

163 Marshall LF, Maas AIR, Marshall SB, et al. A multicentre trial on the efficacy of using tirilazad mesylate in cases of head injury. J Neurosurg 1998;89:519-25.

164 Kassell NF, Haley EC Jr, Apperson-Hansen C, Alves WM. A randomised double-blind, vehicle controlled trial of tirilazad mesylate in patients with aneurysmal subarachnoid haemorrhage: a comparative study in Europe/Australia/New Zealand. J Neurosurg 1996;84:221-8.

165 Jensen K, Ă–hrstrom J, Cold GE, Astrup J. The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension. Acta Neurochir (Wien) 1991;108:116-21.

166 Edwards AD, Wyatt JS, Richardson C, et al. Effects of indomethacin on cerebral haemodynamics in very preterm infants. Lancet 1990;335:1491-5.

167 Muizelaar JP, Marmarou A, Young HA, et al. Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a Phase II trial. J Neurosurg 1993;78:375-82.

168 MRC. Neuroprotection in acute brain injury after trauma and stroke. London: MRC 1998;1-61.

169 Teasdale GM, Graham DI. Craniocerebral trauma: protection and retrieval of the neuronal population after injury. Neurosurgery 1998;43:723-38.

170 Bedford RF, Persing JA, Pobereskin L, Butler A. Lidocaine or thiopental for rapid control of intracranial hypertension? Anaesth Analg 1980;59:435-7.

171 Levene M. Neonatal neurology. Edinburgh: Churchill Livingstone, 1987.

172 Brace DA, Alavi A, Bilaniuk L, et al. Diffuse cerebral swelling following head injuries in children: the syndrome of "malignant brain edema". J Neurosurg 1981;54:170-8.

173 Aldrich EF, Eisenberg HM, Saydjari C, et al. Diffuse brain swelling in severely head-injured children. J Neurosurg 1992;76:450-4.

174 Mazzola CA, Adelson PD. Critical care management of head trauma in children. Crit Care Med 2002;30:S393-401.

175 Downard C, Hulka F, Mullins RJ, et al. Relationship of cerebral perfusion pressure and survival in pediatric brain-injured patients. J Trauma 2000;49:654-8; discussion 658-9.

176 Kaiser G, Pfenninger J. Effect of neurointensive care upon outcome following severe head injuries in childhood - a preliminary report. Neuropediatrics 1984;15:68-75.

177 Ong LC, Dhillon MK, Selladurai BM, Maimunah A, Lye MS. Early posttraumatic seizures in children: clinical and radiological aspects of injury. J Paediatr Child Health 1996;32:173-6.

178 Duhaime AC, Christian C, Moss E, Seidl T. Long-term outcome in infants with the shaking-impact syndrome. Pediatr Neurosurg 1996;24: 292-8.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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