Progressive multifocal leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) is an opportunistic demyelinating infection caused by reactivation of a papovavirus, known as JC virus, and resulting in characteristic unifocal or multifocal white matter lesions.66 The disorder must be distinguished from AIDS dementia complex and cerebral infarction. JC virus can be detected in

CSF by nucleic acid amplification techniques. There is no specific therapy but marked improvement has been shown following immune reconstitution as a result of HAART.67

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