Although effective at preventing eclampsia, there is no evidence to suggest that increasing magnesium serum concentrations to supranormal levels has any benefit in status epilepticus. Indeed, such a policy can result in motor paralysis, difficulty in detecting clinical seizure activity, and hypotension.28 However, serum magnesium can be low in alcoholics and patients with AIDS,29,30 and in these patients intravenous loading with 2-4 g of magnesium sulphate over 20 minutes may help with seizure control and prevention of arrhythmias.

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