Tp53

TP53 is a tumour suppressor gene located at the short arm of chromosome 17. The protein product acts as a transcription factor for cell differentiation, proliferation and death {636,1117,1485}. The role of this gene in salivary gland tumori-genesis remains unknown. Studies of different tumours have yielded variable results {554,1327,2198}. The incidence of p53 expression in other benign, malignant and hybrid tumours is low and does not correlate with recurrence {1823}. At present there is insufficient information on the correlation between p53 and outcome. These unsettling results reflect the lack of technical and interpretative uniformity in assessing this marker {2421}.

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