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Fig. 5.3 Acinic cell carcinoma. A Variably sized luminal or cystic spaces, usually microscopic rather than macroscopic, identifies the microcystic pattern of acinic cell carcinoma. B Microcystic and macrocystic spaces, surrounded by tumour cells and filled with eosinophilic proteinaceous material, resemble thyroid follicles and characterize the follicular pattern, which is an infrequent variant of acinic cell carcinoma. C A prominent lymphocytic infiltrate of the stroma, usually with lymphoid follicles, is common and should not be misinterpreted as evidence of lymph node metastasis.

Fig. 5.3 Acinic cell carcinoma. A Variably sized luminal or cystic spaces, usually microscopic rather than macroscopic, identifies the microcystic pattern of acinic cell carcinoma. B Microcystic and macrocystic spaces, surrounded by tumour cells and filled with eosinophilic proteinaceous material, resemble thyroid follicles and characterize the follicular pattern, which is an infrequent variant of acinic cell carcinoma. C A prominent lymphocytic infiltrate of the stroma, usually with lymphoid follicles, is common and should not be misinterpreted as evidence of lymph node metastasis.

tumour cells from the stromal tissues. The light microscopically clear cells are the result of artefactual changes or dilatations of rough endoplasmic reticu-lum, lipid inclusions, enzymatic degradation of secretory granules, and intracyto-plasmic pseudolumina {398,539,543, 971}.

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