Prognosis and predictive factors

SCCNET is an aggressive tumour with early regional and distant metastasis. Almost half of patients will present with positive cervical lymph nodes and about 60-90% will develop distant metastases, especially to the lungs, liver and bones. The 2- and 5-year survival rates are 16% and 5%, respectively {897}. Because many patients have disseminated disease at the time of diagnosis, radical surgery (laryngectomy with neck dissection) is rarely indicated. Instead a therapeutic protocol using a combination of local radiation and chemotherapy, similar to that for pulmonary SCCNET, is advocated.

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