Prognosis and predictive factors

Most patients have a favourable outcome. In one study, 8% of patients died of disease: 11% and 5% for major and minor gland tumours, respectively. Death correlated with high-grade histopatho-

logic features in minor gland and parotid gland tumours, but not in patients with submandibular gland tumours {921}. Death resulted from unresectable locore-gional tumour, distant metastases or complications of adjunctive therapy {2609}.

The impact of grading on prognosis was described before and, additionally a MIB-1 index >10% correlates with high histopathologic grade, increased recurrence, metastasis and decreased patient survival {2387,2905}. Currently, there are no prognostically useful genetic factors.

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