Prognosis and predictive factors

Adenosquamous carcinoma is reported as being more aggressive than SCC {876,1844,2237,2611}. Many present as high stage tumours. However, stage for stage comparison with SCC has not been well established. In a recent review, 75% of patients had regional lymph node metastases, and 25% of patients had distant metastases {1294}, most commonly to the lungs {731,1294}. The reported 5-year survival rate is 15-25% {831,876,1294}, Half of the patients die of disease after a mean of 23 months (range 12-35 months) {43}.

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