Prognosis and predictive factors

LCS are more indolent than chondrosarcomas arising elsewhere {2598}. This may be due to the fact that LCS are symptomatic at a smaller size when compared to their skeletal counterparts. LCS are managed with conservative surgery {255,1489,2598}. Incomplete resection (shelling out) is associated with local recurrence {2178}. Metastases from LCS, usually pulmonary, are distinctly unusual (<10%), and related to higher grade or dedifferentiation {2598}. LCS related mortality is very low {1489}. Myxoid change involving greater than 10% of the neoplasm correlates adversely with outcome {2598}.

Osteosarcoma

Definition

Osteosarcoma is a malignant tumour characterized by the direct formation of osteoid by neoplastic cells.

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