Prognosis and predictive factors

Myoepithelial carcinomas are locally aggressive salivary gland neoplasms that exhibit diverse clinical outcomes. Approximately one third of patients die of disease, another third have recurrences, mostly multiple, and the remaining third are disease free. Marked cellular pleo-morphism and high proliferative activity correlate with a poor clinical outcome {1827,2251}. There is no difference in clinical behaviour of "de novo" myoepithelial carcinomas and of those arising in pleomorphic adenomas and benign myoepitheliomas {595,2251}.

Fig. 5.30 Myoepithelial carcinoma. A Clear cell myoepithelial carcinoma composed of solid nodules separated by thin fibrous septa. B Epithelioid pleomorphic myoepithelial cells. C Hyaline (plasmacytoid) myoepithelial cells with prominent mitotic activity and abundant eosinophilic cytoplasm. D Spindle-shaped myoepithelial cells with abundant eosinophilic cytoplasm.

Fig. 5.30 Myoepithelial carcinoma. A Clear cell myoepithelial carcinoma composed of solid nodules separated by thin fibrous septa. B Epithelioid pleomorphic myoepithelial cells. C Hyaline (plasmacytoid) myoepithelial cells with prominent mitotic activity and abundant eosinophilic cytoplasm. D Spindle-shaped myoepithelial cells with abundant eosinophilic cytoplasm.

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