Plga

Tubular papillary pattern variable

Mild pleomorphism

Yes

Cellular PA

Syncytial

Uniform

No

AdCC: Adenoid cystic carcinoma;

PLGA: Polymorphous low-grade adenocarcinoma; PA: Pleomorphic adenoma

Fig. 5.8 Adenoid cystic carcinoma. A Tubular form, composed of inner epithelial ductal and outer myoepithelial cells. B Solid form. Tumour cells are small and basaloid with scanty cytoplasm.

radiographical evidence of osseous destruction.

Adenoid cystic carcinoma occasionally occurs with other different neoplasms (hybrid tumours) {505,1823,2297,2416}. Pleomorphic carcinomas and sarcomatoid transformation of adenoid cystic carcinoma have been reported, mostly in recurrent and metastatic disease {397, 418}.

Immunohistochemistry

In differentiating between polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma, Ki-67 immunostaining may be helpful {2680}. DNA content, C-kit and E-cadherin have been found to be associated with the biological behaviour of these tumours {636, 637,1215,1577}. Ki-67 and p53 have also been studied in these tumours {2844}, but no clear association with outcome have been reported. C-kit overexpression and its biological implication remains unknown. None of these markers, however, have been validated. Estrogen and progesterone receptor positivity has been reported in adenoid cystic carcinoma but the biological significance is currently unknown.

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