Pleomorphic adenoma

These amount to 40-70% of minor gland tumours, the large majority of cases being located in the palate, lips and buccal mucosa {2711}. They usually present as painless, slow-growing, sub-mucosal masses, but occasionally they are traumatised and bleed or ulcerate. They rarely exceed 3 sphere cm in diam

Fig. 4.34 A Pleomorphic adenoma. Tumour presenting as a firm swelling on the lateral aspect of the junction between the hard and soft palate. B Plasmacytoid, or hyaline myoepithelial cells are often a conspicuous feature of pleomorphic adenomas of minor glands. C Tumors may have an abundant lipomatous component that is occasionally misinterpreted as invasion. D Multifocal adenomatosis. Both basal cell adenoma and canalicular adenoma can show multifocal tumours and evidence of duct transformation within salivary gland lobules.

eter. Oral pleomorphic adenomas are similar microscopically to tumours elsewhere but frequently lack encapsulation, especially in the palate. They tend to be cellular, and hyaline or plasmacytoid cell types are common. Squamous metaplasia is also frequently seen and may be extensive. Some tumours have a strikingly lipomatous stroma and this should not be misinterpreted as tumour invading fat. Cases of intraoral pleomorphic adenoma with florid pseudoepitheliomatous hyper-plasia of the overlying mucosa have been reported following incisional biopsy {2541}.

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