More florid presentations of HPV-induced lesions are found in immunosuppression, particularly in HIV infection. Lesions may be larger, multiple and coalesce to form extensive patches of affected mucosa. Occasionally the entire oral mucosa may become papillomatous and some of these presentations are not easily classified. Unusual HPV subtypes and multiple HPV subtypes are more frequent in immunosuppression. Occasional lesions in HIV infection are dysplastic and are of uncertain malignant potential.
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