Neuroendocrine tumours

L. Barnes

Neuroendocrine neoplasms of the larynx are a heterogeneous group of tumours that vary from benign to highly malignant. Similar to the lung, they can be divided into several types. As a group, they are uncommon with only about 500 cases recorded in the literature as of 1998 {738}. The atypical carcinoid is the most frequent, constituting 54% of all neuroendocrine tumours in this site, followed by the small cell carcinoma, neuroendocrine type (34%), paraganglioma (9%) and the typical carcinoid (3%) {125,648,897, 2420,2816}.

Cells similar if not identical with Kultchitsky cells of the bronchi are found in the larynx. These, as well as pluripo-tential endobronchial stem cells, are the putative cells of origin of the typical car-cinoid, atypical carcinoid, and small cell carcinoma, neuroendocrine type. Paragangliomas of the larynx are derived from paraganglia normally found in the larynx and are discussed in chapter 8.

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