Metastases to the larynx may be submu-

cosal, cartilaginous or both. If cartilage is involved, it is usually only in the portion which has undergone ossification. The most frequently affected site is the supraglottis (35-40% of all cases) followed by the subglottis (10-20%) and glottis (5-10%). Synchronous involvement of multiple laryngeal sites, however, is common and observed in about 35% of all cases {160,741}. The pyriform sinus is the most frequent site of metastasis in the hypopharynx.

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