SDC is immunoreactive for low- and high-molecular- weight cytokeratin, and markers such as carcinoembryonic antigen (CEA), LeuM1, and epithelial membrane antigen (EMA) {579,1488}. Strong nuclear reactivity for androgen receptors (AR) is reported in all SDC {1265,1488, 2371}. SDC cells are focally positive for

Perineural Invasion
Fig. 5.24 Salivary duct carcinoma. A Note the cribriform ductal component with comedonecrosis and the invasive desmoplastic carcinoma on the right. B Perineural invasion.

¿ ■ ■ ■>. j ■ ■ . - ■ ■ ¿v... - '■

¿ ■ ■ ■>. j ■ ■ . - ■ ■ ¿v... - '■

Pinus Male Cone

Fig. 5.25 Variants of salivary duct carcinoma. A Sarcomatoid variant. B Mucin-rich variant. C Invasive micropapillary variant.

apocrine marker GCDFP-15 and mitochondrial antigen (MIA), and typically negative for S-100 protein, myoepithelial markers, estrogen and progesterone receptors. Variable expression of prosta-tic markers (prostate specific antigen, prostatic acid phosphatase) is seen {555}. The MIB1 proliferative index is high, with an average value of 43% (range 25-80%). Most SDC show positive distinct membrane staining for HER-2/neu protein {1644,2392,2393}.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment