Immunoprofile

SDC is immunoreactive for low- and high-molecular- weight cytokeratin, and markers such as carcinoembryonic antigen (CEA), LeuM1, and epithelial membrane antigen (EMA) {579,1488}. Strong nuclear reactivity for androgen receptors (AR) is reported in all SDC {1265,1488, 2371}. SDC cells are focally positive for

Perineural Invasion
Fig. 5.24 Salivary duct carcinoma. A Note the cribriform ductal component with comedonecrosis and the invasive desmoplastic carcinoma on the right. B Perineural invasion.

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Pinus Male Cone

Fig. 5.25 Variants of salivary duct carcinoma. A Sarcomatoid variant. B Mucin-rich variant. C Invasive micropapillary variant.

apocrine marker GCDFP-15 and mitochondrial antigen (MIA), and typically negative for S-100 protein, myoepithelial markers, estrogen and progesterone receptors. Variable expression of prosta-tic markers (prostate specific antigen, prostatic acid phosphatase) is seen {555}. The MIB1 proliferative index is high, with an average value of 43% (range 25-80%). Most SDC show positive distinct membrane staining for HER-2/neu protein {1644,2392,2393}.

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