ICDOcode90403

Primary synovial sarcoma of the larynx and hypopharynx is rare, while secondary involvement by direct extension from the neck is slightly more common. Although all age groups may be affected, most patients are young and there is no gender bias. Symptoms are non-specific. The tumours are often exophytic or pedunculated, and infiltrative with surface ulceration. Both monophasic and biphasic synovial sarcomas have been described and are similar to the counterpart in the soft tissue. Immunohistochemically, both epithelial and spindle cells may be reactive with cytokeratin and epithelial membrane antigen (EMA), while only the spindle cells are positive for vimentin. Molecular studies reveal a characteristic translocation t(X;18)(p11.2;q11.2). The prognosis is variable but tends to be better than those arising in soft tissue {573,740, 1735,1780,2102}.

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