ICDO code88103

In the past, the term "fibrosarcoma" was often applied indiscriminately to any malignant spindle cell tumour associated with collagen production. On critical review of these cases, supplemented with immunohistochemistry, it has become apparent that many alleged fibrosarcomas are examples of other entities {1636,2191}. With the possible exception of radiation-induced tumours, de novo fibrosarcoma is now recognized as a relatively uncommon tumour {1831}. The main differential diagnoses include spindle cell carcinoma and, occasionally, inflammatory myofibroblastic tumour, posttraumatic spindle cell nodule, and radiation-induced stromal atypia {2604, 2889}.

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