Histopathology

Similar to other primary mesenchymal neoplasms, LOS typically retains a "Grenz zone" of tumour-free, superficial submucosa just beneath the non-dys-plastic epithelium. LOS is uniformly highgrade {1604,2054}, composed of pleo-morphic spindle cells. The amount of osteoid produced by the malignant cells can vary, but characteristic lace-like osteoid is present at least focally {926,1604}. Tumour giant cells may also be identified {198,526,1807}. Laryngeal osteosarcoma may also represent the high-grade sarcomatous component of dedifferentiated chondrosarcoma of the larynx {2675}.

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