Histopathology

CGCE consists of large, slightly eosinophilic cells with granular cytoplasm set in a prominent vasculature. There is no cellular or nuclear pleomorphism, and mitotic activity is not usually observed. The presence of odontogenic epithelium scattered throughout the lesions has been reported. Immunohistochemically, the tumour cells are positive for vimentin and neuron specific enolase; there is no reactivity with cytokeratin, CEA, desmin, hormone receptors or S-100 {1968}. Pseudoepitheliomatous changes in the overlying epithelium, although common in the granular cell tumour, do not occur in CGCE. An extremely rare case of a congenital leiomyomatous epulis has been reported {2542}.

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