The histology of PSCC of salivary origin is similar to that of well- to moderately-differentiated squamous cell carcinoma originating elsewhere in the head and neck. The tumour infiltrates the salivary parenchyma in irregular nests and tra-beculae, accompanied by a fibrous to desmoplastic stromal response. Squamous metaplasia and dysplasia of salivary ducts are occasionally identified in association with PSCC. Perineural invasion and extension into adjacent soft tissue are common findings. There is a significant incidence of cervical nodal metastases (both clinically apparent and occult) at the time of initial surgery {779, 869,1456,2329}.

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