Histopathology

The tumours are similar histologically to the giant cell tumour of bone and, as such, consist of a dual population of cells: mononuclear cells and osteoclast-like giant cells. The mononuclear cells appear as broad sheets of cells reminiscent of histiocytes. They are round, ovoid or spindled and have pink to amphophilic cytoplasm and round, vesicular nuclei with occasional prominent nucleoli. The giant cells are evenly distributed throughout the tumour and contain up to 20 or more nuclei per cell. The nuclei of the giant cells are identical to those of the mononuclear cells. The stroma is vascular and contains many thin-walled vessels with small areas of haemorrhage and haemosiderin-laden macrophages. Mitoses are usually seen, averaging 4 per 10 high power fields (range 1-12 per 10 high power fields) {2785}. Atypical mitoses are not seen.

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