This neoplasm is composed of SCC, but with foci of acantholysis in tumour nests, creating the appearance of glandular differentiation. The pseudolumina usually contain acantholytic and dyskeratotic cells, or cellular debris, but they may be empty {157,742}. They are more frequent in the deeper portions of the tumour. There is no evidence of true glandular differentiation or mucin production. The SCC component predominates, and is usually moderately differentiated. Clear and spindle cells may also be present. The stroma is usually desmoplastic, with a lymphoplasmacytic response {157, 742}. The acantholysis may also form anastomosing spaces and channels mimicking angiosarcoma.

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