Histopathology

The tumour is composed of sheets or rib

Fig. 3.36 Small cell carcinoma, neuroendocrine type. A Low magnification. Note the necrosis. B Small cell carcinoma, neuroendocrine type with lymph node metastases.

Fig. 3.36 Small cell carcinoma, neuroendocrine type. A Low magnification. Note the necrosis. B Small cell carcinoma, neuroendocrine type with lymph node metastases.

bons of closely packed cells with Inconspicuous cytoplasm and round, oval and/or spindle nuclei with dense chromatin and absent nucleoli. Mitoses, necrosis, apoptosis, and lymphatic, vascular, and perineural invasion are common as well as nuclear molding and DNA-coating of the walls of blood vessels. Rare rosettes may be seen. The mucosa is often ulcerated but the marginal epithelium is free of dysplasia. Exceptionally, SCCNET may be associated with a squamous or adenocarcinoma (see "Combined carcinoma" below).

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