Histopathology

The spindle cell component usually forms the bulk of the tumour, which can assume several patterns. Resemblance to fibrosarcoma or malignant fibrous his-tiocytoma is most common {1490,2604}. Occasional cases can appear less malignant and resemble a reactive fibroblastic proliferation or radiation-induced stromal atypia {62}. Foci of osteosarcomatous, chondrosarcoma-tous, or rhabdosarcomatous differentiation may be present, particularly in patients with previous radiotherapy (RT) {1420,1490,2604}. Evidence for squa-mous epithelial derivation can be seen as either in-situ carcinoma or as invasive SCC. Carcinoma-in-situ can be obscured by extensive ulceration. Infiltrating SCC may be focal, requiring multiple sections for demonstration {1482}. Sometimes, only spindle cells are present; in such cases, SPCC can be mistaken for a true sarcoma. (see below). Metastases usually contain SCC alone or both SCC and spindle cell component, and rarely, only the spindle cell component {2457,2604}.

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