Histopathology

The tumour is characterized by a predominant papillary growth pattern {2602}. These papillae have thin fibrovascular cores covered by neoplas-tic, immature basaloid cells or more pleo-morphic cells. Commonly, there is minimal keratosis. Foci of necrosis and haemorrhage are frequent. Multiple PSCC or precursor lesions may occur. Stromal invasion consists of a single or multiple nests of tumour cells with dense lymphoplasmacytic inflammation at the tumour-stromal interface. If no stromal invasion is found, the lesion should be called atypical papillary hyperplasia or PSCC in-situ.

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