Genetics

Recent evidence reveals the presence of anaplastic lymphoma kinase (ALK) gene rearrangements and expression in IMTs {486,949,1440,2865}. These rearrangements are common in IMTs of children and young adults {949,1440,2486} and are uncommon over the age of 40 {367,486,1440}. Both the gene rearrangements and protein activation are restricted to the myofibroblastic component, while the inflammatory cell component is normal {270,466,466,486,486, 949,1440}. Fusion of ALK to Ran-binding protein 2 gene in IMTs expand the spectrum of ALK abnormalities seen in IMT further confirming the clonal, neoplastic nature of IMTs {1593}.

Was this article helpful?

0 0
Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

Get My Free Ebook


Post a comment