Genetics

Only two studies of these tumours have been published. Seven of eight tumours had LOH in at least one marker on chromosome 9p21 {351} in one study. In the other study, a high incidence of LOH was found at 6q,16q, 17p and 17q regions {1110}.

Amplification of HER-2/neu gene and gene product overexpression are reported in SDC {725,1644,1803,2392,2393}. Mutations and overexpression of the TP53 gene and protein are frequent {1110,1803,1823}. Loss of heterozygosi-ty at microsatellite loci, TP53 point mutations and frequent alterations of certain loci on chromosome arm 6q have been reported {1110}. The chromosomal locus 9q21 contains the CDKN2A/p16 tumour suppressor gene that has been implicated in a variety of tumour types, including SDC {351}. More polymorphic genetic markers located at this particular region suggest that inactivation of CDKN2A/p16

Fig. 5.26 The intraductal proliferations of salivary duct carcinoma resemble intraductal breast carcinoma. The tumour forms "rigid" intraductal fenestrations.

gene is associated with progression of SDC {351}.

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