Genetics

There are no individual markers that reliably predict malignant transformation. The molecular biology techniques which show most promise as predictors of development of SCC are large scale genomic status (DNA ploidy) and loss of heterozygosity (LOH) at defined loci {2286}.

Dysplasia has been reported to be present in from 10-25% of leukoplakias

Table 4.03 Malignant transformation of oral leukoplakia (Reibel {2145})

Authors/Year

Country

Material

Observation

Cases with malignant

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