Etiology

HPV infection causes some papillomas {2076} and at least types 1,2,3,4,6,7,10, 11,13,16,18,30,31,32,33,35,38,45,52, 55,57,59,69,72,73 sequences have been detected in benign oral lesions. Clinically, latent HPV is common in oral mucosa and HPV DNA sequences can be detected in over 80% of individuals. There is no absolute association between the virus type and the type of papilloma {866} though focal epithelial hyperplasia is almost exclusively associated with types 13 and 32. HPV infection of oral tissue may be transmitted horizontally, including venereally, perinatally and possibly in utero {2518}.

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